Eli5: why does hand, foot and mouth disease cause sores only on those parts of the body?

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Why does HFM (coxsackie virus) only cause sores on certain parts of the body when other similar diseases (measles, chickenpox, smallpox, etc.) affects all areas of the body?

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The reason that the virus causes sores to develop only on those specific parts of the body is not fully understood. It is thought that the virus may have a preference for certain types of cells or tissues in the body, and that these cells or tissues are more commonly found in the hands, feet, and mouth.

Additionally, the immune system response to the virus may also play a role in the development of the sores. The body’s immune system may produce certain chemicals or proteins that cause inflammation and damage to the cells in the hands, feet, and mouth, leading to the formation of sores.

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