The defense in general exerts more as they are chasing guys but IMO the Dline is really where you have guys getting exhausted. Those guys are going full bore on every play trying to run around or overpower the offensive line while the Oline exerts much less energy by blocking. The Oline simply needs a draw on any play to win while a Dlineman needs to win each snap. You rarely see the secondary or linebackers subbed out other than for making some defensive adjustment like inserting a dime package or short yardage. However, most teams will be rotating 3 levels of Dline depth in throughout the game.
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