eli5: Why is it important to find “patient zero” when trying to understand a disease?

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Doesn’t everyone infected carry the same disease if it has spread?

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Anonymous 0 Comments

There are multiple factors that go into this, so here are the top three that I think are the most important:

– It helps understanding how the disease went from non-issue, to issue. Thinking of COVID, for instance: How the eff did it go from an animal disease, to a human disease, while there didn’t seem to be a possible transmission until then? What is the factor that changed? This alone, could help prevent dire situations of the like in the future.

– It helps understanding how the disease mutated from its origin to now, leading us to a better predictive pattern on how it’ll mutate in the future. Think of it a bit like using dinosaur fossils, and tracing them to modern day birds, giving us a hint as to how evolution works.

– With Patient Zero, they might have the ability to find the original pool of infection, which actually allows to generate the base vaccine/cure, then all you need to do, is follow the strains and strands that came down from it. This is really important, because a vaccine or cure that works against the base infection should at least have a limited efficiency against its variants and strains. A vaccine/cure that works against a specific variant or strain, however, might not work on the base one, because it could be missing large swathes of what the immune system recognize.

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