A few simple differences:
Time only flows in on direction its unidirectional whereas space is omnidirectional, you can go in any direction. (At least until you enter a black holes event horizon then time and space switch roles.)
Your progress through time is not up to you. You always move through time.
These differences are enough to not say 4D spacetime but rather 3+1D spacetime.
But its better to think of space and time as the two parts of a whole.
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