Benadryl knocks me out. But Zyrtec does not.
In: Chemistry
Benadryl is a 1st generation antihistamine which crosses the blood-brain barrier and can therefore affect the brain, causing drowsiness.
Zyrtec is a 2nd generation antihistamine, which does not cross the blood-brain barrier as much as Benadryl, and so has less effects on your brain like drowsiness.
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