The question doesn’t really make sense because you can definitely feel wind blowing on your skin, which is comprised of particles mostly between 28 and 32 atomic units of mass (N2 and O2 molecules). And if you happened to be in a wind tunnel of helium or hydrogen gases, you’d feel those, too (atomic mass of 4 and 2, respectively).
Can you feel a single molecule? Probably not, no matter how large it is. What you “feel” is bulk interaction with a huge number of molecules.
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