Your body is good at protecting itself and sometimes they overreact causing allergies. Pathogens (foreign stimuli) invade the body and the body freaks out because it’s something new so the body will send or produce fighting agents (white blood cells) to fight against it ie rash, hives, conjunctivitis, or severe cases as anaphylaxis.
Medication wise, it depends which form or route it is. If tablet/capsule form, the body has to digest it first or Enteral route that’s why it takes a while to take effect. Diphenhydramine is a good example of this.
If the medication is in liquid form, it can be through Parenteral route ie intravenous, subcutaneous, intradermal, intramuscular injections that goes directly to the circulatory system thus seeing results faster. (Epi-pen) is a good example of this.
Medicine you take by mouth takes a while to get from your mouth->stomach->blood. It also takes a little while to get the concentration of the medicine in your blood to the level where it actually works
That said, you can skip the whole stomach thing by injecting medicine into your blood directly. There’s a drug called adenosine, which is used to reset someone’s heart when they have a dangerous heartbeat. They inject it and within seconds, the patient can feel it. [This](https://youtu.be/WBQrddqWhzo?si=io1jOT-NppO-RidG) is an interesting video showing it in action
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