As the title states, how can people ingest large amounts of sugar from sources and still not get diabetes? Does When you ingest that sugar matter? Like, 39g in the morning, 39g at night (39g being a regular can of coke)?
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Diabetes is just the clinical diagnosis of insulin resistance.
Insulin resistance can be extreme where the body loses ability to pull glucose out of the blood, or it can be very mild where the basal insulin load your body must produce to regulate glucose is higher than it should be.
There’s a lot of good research out there trying to demonstrate that relying solely on blood sugar to diagnose metabolic diabetes is problematic. For example chronically elevated blood pressure is frequently caused by insulin resistance since the kidney re-uptake, or retention of sodium is largely regulated by insulin load. If you’re mildly resistant to insulin you could have perfectly normal blood sugar, but elevated blood pressure.
Insulin resistance is biologically appropriate. When the fall glut of fruit crops up it makes sense for the body to become insulin resistant. More systemic insulin slows down the metabolism, promotes fat gain, and restricts catabolism. Exactly the kinds of things you want for putting on weight before winter. It also blocks leptin signaling on the vagus nerve stimulating appetite. The problem is we never actually go through the famine of winter now.
You can end up with supposed paradoxes in individuals. Being highly active can be protective because that activity helps keep fat from accumulating in the muscles keeping them highly sensitive to insulin allowing them to be a big sink for that glucose. Additionally eating patterns can greatly influence insulin sensitivity. Eating 200g of sugar throughout the day is completely different than eating 200g in one sitting. In one sitting you have one insulin spike, and the rest of the day you have low insulin which promotes catabolism and moving fat away from the organs. If you graze all day the catabolic state is never really achieved.
That’s how you can end up with people who weigh 300lbs but paradoxically have hardly any symptoms associated with metabolic disease. They have no visceral or organ fat. Then you have perfectly normal weight individuals with high blood pressure, diabetes, and a littany of health complaints, but they have high amounts of visceral fat and intramuscular fat.
Get a fasting insulin test. Aboriginal hunter-gatherer populations have fasting insulin around 3.2-3.5. If i remember correctly The women’s health initiative study found a doubling of all cause mortality within 5 years with a fasting insulin of 8.0 vs 7.0. If you get a fasting insulin test it will say you are “normal” if you are under 15…. that normality is based on blood sugar outcome. Not health outcomes. If you’re over 5.0 you are insulin resistant.
Diabetes is just the clinical diagnosis of insulin resistance.
Insulin resistance can be extreme where the body loses ability to pull glucose out of the blood, or it can be very mild where the basal insulin load your body must produce to regulate glucose is higher than it should be.
There’s a lot of good research out there trying to demonstrate that relying solely on blood sugar to diagnose metabolic diabetes is problematic. For example chronically elevated blood pressure is frequently caused by insulin resistance since the kidney re-uptake, or retention of sodium is largely regulated by insulin load. If you’re mildly resistant to insulin you could have perfectly normal blood sugar, but elevated blood pressure.
Insulin resistance is biologically appropriate. When the fall glut of fruit crops up it makes sense for the body to become insulin resistant. More systemic insulin slows down the metabolism, promotes fat gain, and restricts catabolism. Exactly the kinds of things you want for putting on weight before winter. It also blocks leptin signaling on the vagus nerve stimulating appetite. The problem is we never actually go through the famine of winter now.
You can end up with supposed paradoxes in individuals. Being highly active can be protective because that activity helps keep fat from accumulating in the muscles keeping them highly sensitive to insulin allowing them to be a big sink for that glucose. Additionally eating patterns can greatly influence insulin sensitivity. Eating 200g of sugar throughout the day is completely different than eating 200g in one sitting. In one sitting you have one insulin spike, and the rest of the day you have low insulin which promotes catabolism and moving fat away from the organs. If you graze all day the catabolic state is never really achieved.
That’s how you can end up with people who weigh 300lbs but paradoxically have hardly any symptoms associated with metabolic disease. They have no visceral or organ fat. Then you have perfectly normal weight individuals with high blood pressure, diabetes, and a littany of health complaints, but they have high amounts of visceral fat and intramuscular fat.
Get a fasting insulin test. Aboriginal hunter-gatherer populations have fasting insulin around 3.2-3.5. If i remember correctly The women’s health initiative study found a doubling of all cause mortality within 5 years with a fasting insulin of 8.0 vs 7.0. If you get a fasting insulin test it will say you are “normal” if you are under 15…. that normality is based on blood sugar outcome. Not health outcomes. If you’re over 5.0 you are insulin resistant.
The main factor is total calories. As long as they aren’t overconsuming calories having lots of sugar isn’t that bad.
The main issue is the large amounts of sugar is that it means that people can easily overconsume calories.
The main factor is total calories. As long as they aren’t overconsuming calories having lots of sugar isn’t that bad.
The main issue is the large amounts of sugar is that it means that people can easily overconsume calories.
The main factor is total calories. As long as they aren’t overconsuming calories having lots of sugar isn’t that bad.
The main issue is the large amounts of sugar is that it means that people can easily overconsume calories.
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