I used to work in a vet clinic.
We gave the animals a cocktail of pre anesthesia, and then [euthasol ](https://en.m.wikipedia.org/wiki/Phenytoin/pentobarbital)
If the animal was a stray they became docile with the pre anesthesia, enough to administer the euthanasia.
I preferred to do IC sticks or inter cardiac injection. It was quicker than IV, the animal would pass before I got the plunger all the way down. And it’s easier to find the heart than it is to find the vein. Some folks prefer IV sticks.
It’s probably the most humane way to put the animal down. We only did animals that were non adoptable, like stray/feral cats, injured animals or aggressive dogs.
Euthasol is a controlled drug, and the manufacturers won’t sell it for human use. Like any narcotic it’s dosed by body weight so it would take a significant amount to put a human down.
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