I make a double shot with around 16g of coffee and 250ml of drip coffee with around 15g of coffee, so they are actually very comparable in terms of total coffee.
The difference in brew time and pressure means that you have different ratios of soluble compounds, but I actually think that the amount of caffeine is around the same for the same amount of coffee, e.g. around 100mg. Technically, the longer brew time would mean that more of the relatively non-polar caffeine (compared to things like sugars) would be extracted in drip coffee, but most of the caffeine is extracted fairly early on, so the actual difference is fairly minimal for the same starting mass of coffee. Some people do prefer stronger drip coffee of weaker espresso, meaning there can be a lot of overlap.
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