How come just a 2 degrees increase of body temperature can make you feel so fatigue and like you’re dying?

Question

It doesn’t seem like a huge difference to me but even a 1 degree increase of body temp can make you so tired and have fever. Why is that?

In: 2376

Answer 1

Enzymatic reactions in your body are very sensitive to temperature. 2 degrees of difference can set off a cascade of negative effects that fuel each other.