How come just a 2 degrees increase of body temperature can make you feel so fatigue and like you’re dying?

Question

It doesn’t seem like a huge difference to me but even a 1 degree increase of body temp can make you so tired and have fever. Why is that?

In: 2376

Answer 1

To ELI5 it: the same chemicals that lead to a fever also cause your body to be more sensitive to pain, cause inflammation at the site of infection, and cause you to be fatigued.

It’s the interleukins that make you feel like shit. Which is why when you are outside in the heat your temp may be 100.4F but you don’t feel like shit