Avogadro’s number is the number of particles (atoms or molecules) of a substance such that the atomic mass in amu’s of a single particle is equal to the mass of all the particles together in grams. Avogadro was the first to conceptualize such a number when he proposed that the pressure of a gas is directly proportional to the number of particles in that gas, but he didn’t actually calculate what it was. It was just known to exist. German physicist Josef Loschmidt was the first one to estimate the number mathematically based on the ideal gas law equation.
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