Others have already pointed out that Europe, Asia, and Africa had plenty of contact and intermingling with each other. (really, Europe and Asia are geographically their own continent) But another factor is the lower prevalence of animal agriculture in the pre-Columbian Americas. A lot of diseases came about because of humans and animals living in close proximity. (and think of the waste!) People in the early Americans did have domesticated animals, but didn’t use animal agriculture to the same extent, and the species they did use didn’t seem to bring them disease. (at least, not the kinds of diseases that Old World people had)
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