It depends on the drug, but basically you have been feeding your brain a chemical it likes and has gotten used to, so when you stop taking it your brain and body gets kinda pissy about it.
So nicotine, the reason people smoke, is a stimulant. When you smoke you get a little bit of feel-good, and your body and mind becomes used to it. When you stop your body sends out signals saying “hey, I want my feel-good! I should be feeling different! Something is wrong!”
Some drugs can become such an important part of your life that stopping them too quickly will literally kill you. Alcohol withdrawals, for example, can kill you if it’s severe enough. Heroin withdrawals, ironically, will not. Weed is fat soluble so you basically wean yourself off when you quit, and that’s why you might hear people say it isn’t addictive.
You also have psychological addictions as well. That basically just means it is all mental and there isn’t a physical component to it.
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