It all comes down to type of antibiotics. Each class of antibiotic has a different mechanism of action, such as inhibiting protein synthesis by targeting different processes in the protein synthesis pathway, inhibiting bacterial cell wall growth, inhibiting ATP synthesis and so forth. C diff infections can arise when taking broad-spectrum antibiotics for other infections. Since C diff is normal flora in our GI tract (normally not a problem until they replicate to large amounts) it can become prevalent when surrounding bacteria are killed by said antibiotics but aren’t affected and are able to grow and replicate. This is the concept of “competition” and space in the GI tract. To then treat C diff you would use more specifically targeted antibiotics. That’s why it’s suggested you eat yogurt or take probiotics when on antibiotics, so as to replace the commensalistic bacteria that are being killed
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