Very carefully.
If left to their own devices, inbreeding will likely be a problem, but with human intervention, we can help.
Basically we can create a healthy gene pool from 50 healthy individuals, and we can leave them be to reproduce on their own with 500 healthy individuals.
These are just general guidelines and doesn’t apply if there is already heavy inbreeding or all the individuals are already related. In any case, the more individuals, the better.
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