The flight coridors are seperated by altitude. Flights going east keep to odd hundreds of feet and flights going west keep to even hundreds of feet. They all use a barometer calibrated to the same value for sea level and a magnetic compass. Even if these technically show wrong compared to true altitude and true heading any fancy GPS, radio navigation or innertial navigation instruments need to calculate what a simple barometer and magnetic compass would show because this is the standard. So as long as everyone follows these rules there are always at least a hundred feet between airplanes flying in different directions.
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