How do psychedelics affect the brain that people experience insane things so quickly or intensely?
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Nobody really knows. The vast majority of psychedelics affect your serotonin system, it seems they generally produce more serotonin but also the actual molecule of the drug itself fits into serotonin receptors. This varies in effect too, psilocin and LSD generally fit into this profile, but then you have drugs like salvinorin (salvia) which primarily effects dopamine and also usually causes dysphoria (most psychedelics cause euphoria). Salvia is interesting because it is arguably the most intense and immediate “””psychedelic”” but it’s different from all of the others. The long answer, and the short answer, are that nobody truly knows exactly why they do what they do. There has also been an increasingly strong contingent of people arguing that DMT is a neurotransmitter. It’s been found present in at least human lung tissue and various other human tissue, and is in many other natural organisms. It also is burned up by the body in about 5 minutes even when consumed at like the 100mg dose, so it being a tiny tiny little bit of your body’s neurotransmitters, like in the micrograms, seems plausible and the implications of that and our connection to reality are something that is a whole other conversation.
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