How do SSRI withdrawals cause ‘brain zaps’?

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It feels similar to being electrocuted or having little lighting in your brain, i’m just curious as to what’s actually happening?

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Had them with both Effexor and Viibryd (sp?). I stopped anti-depressants for years because I couldn’t seem to find one that didn’t have absolutely terrible and/or debilitating side effects. Been on Wellbutrin for a few 6 months now, and the side effects are mild and I actually feel like a functional human being for the first time in forever.

Anyway, brain zaps were the absolute worst side effect. If you’ve never experienced them, it’s difficult to even describe it.

Anonymous 0 Comments

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Anonymous 0 Comments

Multitude of reasons could apply here. We don’t actually know how SSRI’s work and which systems of the nervous system are actually affected. What I can tell you is that you definitely didn’t “feel” your brain. Your brain doesn’t have sensory or pain receptors, so what you felt was more likely the meninges or a related area. This could theoretically be related to vasoconstriction, like a lot of sensations surrounding the brain. But as I said, the pathways of how SSRI’s actually work are largely unexplored.

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No one knows. Much more common with some medications. The King is Effexor, or as I like to call it, Side Effexor