How do SSRI withdrawals cause ‘brain zaps’?

517 views

It feels similar to being electrocuted or having little lighting in your brain, i’m just curious as to what’s actually happening?

In: 188

22 Answers

Anonymous 0 Comments

Serotonin and norepinephrine, two neurotransmitters targeted by antidepressants, modulate pain signal processing in the body. Both neurotransmitters may have an inhibitory effect on pain, and when removed, the pain can rebound. In other words, brain zaps could represent the “waking up” of nerve cells that were previously inhibited from firing.

Marks DM, Shah MJ, Patkar AA, Masand PS, Park GY, Pae CU. Serotonin-norepinephrine reuptake inhibitors for pain control: premise and promise. Curr Neuropharmacol. 2009 Dec;7(4):331-6. doi: 10.2174/157015909790031201. PMID: 20514212; PMCID: PMC2811866.

Edit: Thank you for the gold, kind redditors!
Edit2: Thank you for all the awards!

You are viewing 1 out of 22 answers, click here to view all answers.