Serotonin and norepinephrine, two neurotransmitters targeted by antidepressants, modulate pain signal processing in the body. Both neurotransmitters may have an inhibitory effect on pain, and when removed, the pain can rebound. In other words, brain zaps could represent the “waking up” of nerve cells that were previously inhibited from firing.
Marks DM, Shah MJ, Patkar AA, Masand PS, Park GY, Pae CU. Serotonin-norepinephrine reuptake inhibitors for pain control: premise and promise. Curr Neuropharmacol. 2009 Dec;7(4):331-6. doi: 10.2174/157015909790031201. PMID: 20514212; PMCID: PMC2811866.
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