Medicines, vitamins and other chemicals are generally either water soluble or fat soluble. Water soluble chemicals can be absorbed directly into your bloodstream and don’t need to be taken with food. But fat-soluble chemicals won’t dissolve in water, and thus need some fat in your stomach. Generally when a pill is suggested to take “with food” or “with a meal”, it’s because it’s fat-soluble and almost all food has at least some fat/oil/lipids in it, so they don’t bother to specify what kind of food.
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