Frostbite is a very real possibility. Most doctors would recommend only applying an ice pack for a maximum of 20 minutes at a time within a 2 hour period. Additionally, placing a thin barrier like a towel between the ice pack and the skin is advisable as this causes the heat loss to be spread over a larger area preventing a rapid drop in temperature in a small area which would lead to ice burn.
Typically, frostbite resulting from ice packs is very minor and can be resolved by soaking the effected area in warm, but not hot water (~105 degrees Fahrenheit).
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