In a simple blind study, the project leader knows which drug I am taking. There is a good chance that the effect of the drug on me is triggered by the placebo effect. But why is my placebo effect alleviated if the project leader does not know what I am taking either?
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It doesn’t. The point is that both arms will experience the placebo effect. So if the treatment works better you know it’s not just the placebo effect. It lets you compare the arms against each other on similar footing.
As other posters said if the doctor knows if you’re receiving treatment or placebo they might accidently interact with one arm or the other differently.
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