Dust is not any one thing. It’s tiny particles suspended in the air. Yes some of it is skin cells, some of it is air, some of it is dirt, some of it is pollen, some of it is just pretty much anything that’s been ground to dust, very small particles, and swept up by the air and taken everywhere. Keeping dust to a minimum in a closed off space requires that it’s more or less airtight, as in no new air is coming in and the air inside is stagnant and not moving. That won’t prevent the dust that is already in there from settling but it will mostly prevent new dust from entering.
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