Not that much on its own. Humans quite possibly can survive such pressure and even some more; I don’t think we ever got that extreme, though. One third that pressure was done, I think. Most importantly they need to carefully adapt to it and need very special air supply, maybe even some extra treatment.
However, the change, especially if quick, is what really causes much of the issue. It can very easily mess up all steps of how oxygen gets to the cells, leading to asphyxiation as well as clogging, hence strokes. Typically, death follows.
The force itself is equalized out over your body, coming from all directions equally. If for some reason there is a difference, water/air will try to flow through and the tremendous force will not really stopped by a human; they will get squished, broken and turned into pulp if necessary.
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