Receptors have preferences for different things that can bind to them. The more a receptor would prefer to bind to one substance, the more likely it is to kick off another substance. It’s kind of like if you’re offered a Diet Coke — you like Diet Coke so you’ll drink it, but you **really** like Dr. Pepper. If someone comes along and offers you a Dr. Pepper, you’ll toss the Diet Coke to the side and start drinking the Dr. Pepper instead. The various receptors in your body that opioids bind to have a much stronger preference for Narcan than the opioid drugs
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