Screening is rigorous, but some astronauts do come down with space rashes. This is because the redistribution of blood and liquids in you body alter your immune system regulation and some latent viruses will emerge while in space. The result is a rash.
[Space Rash](https://www.sakshipost.com/news/why-astronauts-develop-skin-rashes-viral-infections-space-203584)
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