It’s actually a misconception that white blood cells are in the blood stream, they’re everywhere, in blood and living dormant in tissues. So immune cells can attack things in their neighborhood—and the airway is chock full of resident immune cells
Certain types of white blood cells in the blood also know how to stick onto bacteria and viruses, and when they do, others are attracted to and begin sticking to the original guy, which can build an immune response.
I’m going really ELI5 here but it beats the insane language that immunologists use to describe things
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