I never really understood how people built up a tolerance to nicotine or spicy food. Maybe something to do with nerves?
In: Biology
Spicy food contain capsaicine which binds to a receptor called TRPV1 presents on the nociceptive neurons, aka neurons that detect that something wrong is going on in your body that thus in the lead to the pain sensation.
Capsaicine desensitize TRPV1 after a while and thus the nociceptive neurons get less activated. Thus you will lose the sensibility to capsaicine for a while.
Nicotine kinda do the same but on other receptors in the brain. The cholinergic receptors get desensitized and thus you start to need more and more nicotine to activate them.
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