Sometimes it’s because of where the venom is, and the creature would indeed be harmed if the venom made its way into their blood, but because the venom sacs keep the venom separate, it’s not an issue.
Sometimes it’s because it reacts with some biology that is different in different animals. Sometimes an animal will be resistant to poison produced by something it eats, and in some cases can even accumulate that poison for its own defense. An example of this is poison dart frogs.
Some toxins do not activate unless they see distinctly human chemicals. All of our cells have sugars and proteins on the outside, different sugars/proteins indicate different types of cells. If the toxin attaches to a sugar it knows is found in human lungs, it will turn on. Otherwise it just floats around harmlessly.
It’s like a gun with a safety on, or taser with no batteries, until it connects to the right cell. This is one method of toxin activation, but there are others as well.
We have stomach acid that has a pH of 2.0 or less. So why doesn’t it harm us by essentially “digesting” us? Mucus covers the stomach wall with a protective coating. We also have bicarbonate which neutralizes it and makes sure that the stomach wall itself is not damaged by the hydrochloric acid.
It’s in a part of our body with measures to make sure it stays in that part of the body and doesn’t harm anything else. Same principle applies to venom in animals.
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