The same way you’re unaffected sitting in a car going 75mph in a straight line. You only feel anything when the car accellerates in any direction, such as speeding up, slowing down, or turning. When the car is moving at a constant speed with no changes in direction, you feel at rest. It works the same way in an airplane going 400mph. It’s no different for the people on the Internation Space Station.
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