How is it the ISS can travel at 17,400 MPH, but astronauts seem unaffected at all?

Question

EDIT: Thank you all for your kind yet informative responses!

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Answer 1

When you travel 60km/h in a car, what do you feel? If you drop something from your hand, it’ll fall straight down because no other force affects it. Humans can’t sense speed – they can sense acceleration?