How is the compound library selected for drug discovery in a phenotypic screening method where we do not know the target initially?

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How is the compound library selected for drug discovery in a phenotypic screening method where we do not know the target initially?

In: Biology

Can you ask the question like I’M five?

Companies make large libraries of chemicals specifically designed for these types of screens and you just use one of those. I have no idea how to make this more explanatory and also eli5, but basically the goal is to make the components of the library very diverse – meaning you have some compounds that react with all of the important major biochemical pathways at different points. They also look at all sorts of chemical properties of the compounds, to see how many hydrogen acceptors/donors there are, various chemical groups, structures, etc, and use software to determine how they can get the most diversity in all of these things in the number of compounds they want to have in the library.