If 2 sets of twins had kids, would those kids also be siblings?

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If you had two separate sets of twins, say one set is male and the other female, and they coupled up and eventually had kids, would their kids be siblings or cousins on a DNA level?

This is just wildly hypothetical, but I saw a clickbait ad somewhere about a story, and now I’m curious if there’s any validity to it. It said the kids would all have matching DNA and were siblings

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Anonymous 0 Comments

More or less. In a simple version of genetics, where genes are not modified at all during a living creature’s lifespan, then yes, children of two couples of identical twins would be as genetically related to one another as siblings of a typical couple are. (On average, they would share half of their genes with each sibling, although there’s plenty of variance around this average.)

It’s worth noting that there’s a lot of “um, actually…”s in genetics, though. *Most* genes are passed down unaltered, but not all (since your body can “turn off” or “turn on” genes in ways that can be passed on).

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