There’s a couple things that lower the possibility of overdose. First being tolerance, people who use fentanyl on the street usually have a very high tolerance to opiates and they will be able to withstand a higher dosage of fentanyl without od. Another is the way pharmaceutical fentanyl is manufactured and designed, most fentanyl prescribed is used through a patch, which limits the amount of fentanyl released into the bloodstream. Some patches will slowly release the dose over a period of 24 hours or longer. Hope I was able to help a bit, let me know if I can answer any questions you have
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