If a health worker gets tested weekly when swab test has like x% false positive chance, wouldn’t the person almost certainly gets falsely tested once?

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If a health worker gets tested weekly when swab test has like x% false positive chance, wouldn’t the person almost certainly gets falsely tested once?

In: Biology

4 Answers

Anonymous 0 Comments

It depends on the specificity of the test.

Tests like that don’t really have a “false positive rate” – there will be a certain number of false positives for every true negative (specificity), but the % of positives overall that are false also depends on the number of true positives, which depends on how prevalent the disease is in the population being tested.

If the “population” just consists of 1 person being tested over and over, but they’re never actually infected, the false positive rate will be either 0% or 100%, because there will never be any true positives. But if the specificity is really high (a low rate of false positives to true negatives), it may not really matter in a practical sense.

If the specificity is 95%, then 5/100 would be false positives, so if you get tested every week for a year (52 times), there’s a 93% chance of at least one false positive.

But if the specificity is 99%, the odds of a false positive after 52 tests drops to 41%. And if it’s 99.9% specific, then it’s only 5%.

The actual specificity of PCR tests is estimated to be about 98-99%.

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