Galaxies are made of stuff, *lots* of stuff. Enough that even if there wasn’t any light coming from it, we could be able to see that stuff was there from the gravity warping light from behind it.
So no, there can’t be a “new” Galaxy closer than Andromeda that we just haven’t seen yet, because the stuff that makes up the galaxy would have to have been there already.
As for farther away, it’s possible that they have moved and combined so much as to have new galaxies form in the time that the light has been traveling, but it’s not a “dark spot”, because even if there isn’t a galaxy there, there’s probably other galaxies behind it that are just dimmer.
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