if artificial plastics are (mostly) chemically inert, why do they pose such a high biological risk to lifeforms?

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We keep hearing the word “microplastic” in our foods, seas, and ground, but if they do not react with most chemicals, why are they a problem in our bodies? Wouldn’t they just ignore them?

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What goes in, often comes out. If it doesn’t, then it’s either stuck or incorporated into the body (i.e. some chemical reaction occurs). The problem with highly stable compounds entering the body is due to accumulation over time and chronic exposure. This is a possible issue with microplastics for this same reason. Ingesting it as a small particle can lead to accumulation in the small nooks and crannies of our digestive system, and perhaps even our respiratory system if airborne (see: silicosis).

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