Testosterone is a hormone. Hormones are chemicals that affect our bodies in very complex ways. We have many hormones and they often affect each other and balance each other out. They control basically everything in our bodies, from blood sugar and blood pressure, digestion, reproductive functions, growth, sleep, etc., even emotions.
Of course, “natural” is subjective and relative. But when you take hormones, you are in a way changing your body “from within” and you often have to take several other hormones and/or hormone blockers to try to keep balance and prevent various side effects. On the other hand, creatine is relatively harmless meaning it doesn’t affect a lot of stuff in the body the way hormones do.
I’m not an expert and I hope someone will correct me if I got something wrong.
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