If both liver and kidneys are cleaning the blood, what’s the difference between them?

Question

If both liver and kidneys are cleaning the blood, what’s the difference between them?

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Answer 1

Easiest way to think about it is that the kidneys filter water soluble solutes and the liver filters fat soluble solutes. They also both have other functions beyond filtration…the liver produces lipoprotein “cholesterols” that transport fat soluble solutes throughout the body. The kidneys produce erythropoietin (which is responsible for red blood cell production), regulate blood pressure, and manage electrolyte balance.