After waking up my adenosine level should be very low and l slowly build up upon the day. So why does my morning coffee make me feel awake if there is no adenison to block?
In: 25
why do you think there is no (or low amounts) of adenosine circulating through your body when you wake up?
Low not 0. Caffeine make feel like zero.
When wake up, adenosine low, not 0. Must act to get adenosine 0.
Caffeine cover up adenosine, making no sleepy, till caffeine start to wear away, then sleepy come back.
Over time, your neurons counteract the effects of caffeine exposure by producing more adenosine receptors. With more receptors, your neurons become more sensitive to low levels of adenosine. This leads you to need more caffeine to feel its effects, and some caffeine to feel “normal.”
[source](https://pubmed.ncbi.nlm.nih.gov/1888264/)
2 ways that I know of: if you’re one of those people that yawns when they get up, there’s still some residual adenosine to get rid of. And/or your body is addicted to caffeine so you need it to function correctly
You are very much on the right track already. Adenosine can be thought of as a metabolic product that builds up over the day as a result of your brain’s normal functioning. ***But there is always some around***. As you correctly suggest, binding of Adenosine to Adenosine receptors is in part responsible for feeling tired and sleepy. Caffeine can bind to the adenosine receptor first (without actually activating it – like putting glue in a keyhole), and it prevents adenosine from binding, which prevents you from experiencing those signals of feeling tired.Further, sometimes, an antagonist like caffeine can remove adenosine ***already bound to a receptor*** as well. This effect can promote wakefulness by terminating adenosine’s suppressing effects quickly.
Little tip for you. To help reduce the 2pm crash, wait over 90/120 minutes for your first coffee if you can.
Thanks for your comments, it’s much more understandable for me now! 🙂
Wait till you have limonine(nene? I can never remember) before your caffeine!!!
Get some o that fresh squeezed lemon skin juice in you before coffee. Gives you Laser eyes!!
Because it blocks the receptors for Adenison, which is responsible for feeling tired/exhausted.
After waking up my adenosine level should be very low and l slowly build up upon the day. So why does my morning coffee make me feel awake if there is no adenison to block?
In: 25
why do you think there is no (or low amounts) of adenosine circulating through your body when you wake up?
Low not 0. Caffeine make feel like zero.
When wake up, adenosine low, not 0. Must act to get adenosine 0.
Caffeine cover up adenosine, making no sleepy, till caffeine start to wear away, then sleepy come back.
Over time, your neurons counteract the effects of caffeine exposure by producing more adenosine receptors. With more receptors, your neurons become more sensitive to low levels of adenosine. This leads you to need more caffeine to feel its effects, and some caffeine to feel “normal.”
[source](https://pubmed.ncbi.nlm.nih.gov/1888264/)
2 ways that I know of: if you’re one of those people that yawns when they get up, there’s still some residual adenosine to get rid of. And/or your body is addicted to caffeine so you need it to function correctly
You are very much on the right track already. Adenosine can be thought of as a metabolic product that builds up over the day as a result of your brain’s normal functioning. ***But there is always some around***. As you correctly suggest, binding of Adenosine to Adenosine receptors is in part responsible for feeling tired and sleepy. Caffeine can bind to the adenosine receptor first (without actually activating it – like putting glue in a keyhole), and it prevents adenosine from binding, which prevents you from experiencing those signals of feeling tired.Further, sometimes, an antagonist like caffeine can remove adenosine ***already bound to a receptor*** as well. This effect can promote wakefulness by terminating adenosine’s suppressing effects quickly.
Little tip for you. To help reduce the 2pm crash, wait over 90/120 minutes for your first coffee if you can.
Thanks for your comments, it’s much more understandable for me now! 🙂
Wait till you have limonine(nene? I can never remember) before your caffeine!!!
Get some o that fresh squeezed lemon skin juice in you before coffee. Gives you Laser eyes!!
Because it blocks the receptors for Adenison, which is responsible for feeling tired/exhausted.
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