Say you’ve gone through Radiation treatments, which is known to create DNA mutations, or you’ve smoked for several years also known to create mutations, Wouldn’t a Genetics test pick that up?
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Mutations only occur in one cell. They may then spread to all of that cell’s descendants, but a bunch of mutant white blood cells or colon lining cells wouldn’t appear in your typical saliva swab DNA test, nor would they be passed down to your offspring.
The tests are also collecting an aggregate from multiple cells, so one mutant in the bunch is unlikely to register compared to the healthy ones.
We do sequence cancer cells specifically sometimes though, as they will have anomalous DNA and are all related.
Spontaneous Genetic mutations in adults don’t enter the gene pool unless it’s a mutation to a reproductive cell and that results in a baby. One cell mutated in an adult only matters if it turns cancerous, which is something medicine does test for. But testing for one cell’s mutation would be almost impossible… your body has billions of cells, and finding that one would be very very improbable, and most of those cells would most likely not effect the overall body anyway.
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