DNA holds the instructions for each cell in every tissue of your body for how to build the machinery and structure that makes the cells work. Some changes to DNA will change the way that a particular machine works, like how there are different kinds of drills and different kinds of screws. But many (most? This is hotly debated) of the important changes are when and where and how much of the machinery and structure proteins each cell makes. You could build many different shapes of houses with the same tools and same materials, depending on how (when and where and how much) you put them together.
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