Hypertrophy is generally obtained via a few variables:
Mechanical tension, metabolic stress and muscle damage.
50 squats at once will certainly tick the box for metabolic stress much better, and would do for muscle damage. Mechanical tension, perhaps the jury is out on that one.
From a strength point of view, the sets of 10 spread out, could potentially be better in terms of skill development for the squat, ala greasing the groove
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