If migraines are thought to be due to CGRP, why does it feel like migraines usually start in the neck and shoulders?
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So let’s start by saying it’s not thought it is due to that. It may possibly be due to that, but that’s very preliminary. No one study will ever prove anything, there are some hints they may be related but the nature of the effect and relation is very much a ‘maybe’ at this point.
To more substantively answer how that would affect things, CGRP is released and the receptors are in the meninges, which is a sack around your central nervous system which includes your brain but also your brain stem and spinal cord. It’s very much present in your neck and just below.
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