if procreating with close relatives causes dangerous mutations and increased risks of disease, how did isolated groups of humans deal with it?

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if procreating with close relatives causes dangerous mutations and increased risks of disease, how did isolated groups of humans deal with it?

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When isolated groups of humans have to make babies with people who they are related to, they can have babies with people who are not as closely related as a brother or sister. For example, if two cousins wanted to have a baby, that would be less risky than if a brother and sister wanted to have a baby. This means that the baby would still have a chance of getting some of the same genes, but not as many as if the parents were more closely related.

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