if procreating with close relatives causes dangerous mutations and increased risks of disease, how did isolated groups of humans deal with it?

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if procreating with close relatives causes dangerous mutations and increased risks of disease, how did isolated groups of humans deal with it?

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Just because in has increased risks doesn’t mean it won’t work. If you went from a 5% chance of having a child with serious defects to a 50% chance of having a child with serious defects, you still have a 50% chance of bearing a child who doesn’t have serious defects. If a small group of isolated people gets lucky, they can still survive and prosper. Some isolated groups of humans died out, and some managed to survive.

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