You could, and we kinda do. We use [RTGs](https://en.wikipedia.org/wiki/Radioisotope_thermoelectric_generator) in spacecraft and other more niche applications. Containment and contamination are always a concern, so you don’t see much of this type of tech in consumer applications besides some old 1st-gen pacemakers I think. I don’t know if the plutonium in those is actually from power plants however, so I’m not sure if RTG fuel is technically “waste” material.
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