The hangover is partially a result of alcohol’s tendency to replicate the activity of GABA (the neurotransmitter) and thus interfering with your brain’s natural activity. You end up literally pissing away a whole lot of GABA when you urinate during a drinking session.
As your brain detoxifies and goes back to using GABA (please forgive my clumsy command of English), you start to feel worse and then better.
This is not prevented by the drinking of water.
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